Preventive Care6 min readDec 8, 2025

Flu Season 2025-26: CDC Reports and Treatment Guidelines

Influenza (flu) is a contagious respiratory illness that affects millions of Americans each year. According to the CDC, seasonal flu causes an estimated 9-41 million illnesses, 140,000-710,000 hospitalizations, and 12,000-52,000 deaths annually in the United States. Understanding prevention and treatment options can help you and your family stay healthy.

Flu vs. Cold: Know the Difference

While both are respiratory illnesses, flu symptoms are typically more severe:

  • •Sudden onset (flu) vs. gradual onset (cold)
  • •High fever (flu) vs. mild/no fever (cold)
  • •Severe body aches (flu) vs. mild aches (cold)
  • •Extreme fatigue (flu) vs. mild tiredness (cold)
  • •Dry cough (flu) vs. productive cough (cold)
  • •Headache common (flu) vs. rare (cold)

Prevention: The Flu Vaccine

Annual flu vaccination remains the best protection:

  • •Recommended for everyone 6 months and older
  • •Best received by end of October, but beneficial any time during flu season
  • •Takes about 2 weeks to develop full protection
  • •Even if you get flu after vaccination, symptoms are often milder
  • •Reduces risk of flu-related hospitalization

The flu vaccine cannot give you the flu. It contains either inactivated virus or no virus at all (recombinant vaccines).

High-Risk Groups

Some people are at higher risk for flu complications:

  • •Adults 65 and older
  • •Children under 5, especially under 2
  • •Pregnant women
  • •People with chronic conditions (asthma, diabetes, heart disease)
  • •Immunocompromised individuals
  • •Nursing home residents
  • •American Indians/Alaska Natives

Antiviral Treatment

Antiviral medications can shorten flu duration and reduce severity:

  • •Oseltamivir (Tamiflu): Oral medication, most commonly prescribed
  • •Zanamivir (Relenza): Inhaled medication
  • •Peramivir (Rapivab): IV medication for hospitalized patients
  • •Baloxavir (Xofluza): Single-dose oral medication

Antivirals work best when started within 48 hours of symptom onset. If you're high-risk, contact us immediately when symptoms begin.

When to Seek Care

Contact your healthcare provider if:

  • •You're in a high-risk group with flu symptoms
  • •Symptoms are severe or worsening
  • •You have difficulty breathing
  • •Symptoms improve then return with fever and worse cough
  • •You have chronic conditions that could be affected

Emergency Warning Signs

Seek emergency care immediately for:

  • •Difficulty breathing or shortness of breath
  • •Persistent pain or pressure in chest/abdomen
  • •Persistent dizziness or confusion
  • •Seizures
  • •Severe muscle pain
  • •Not urinating (dehydration)
  • •In children: bluish skin, not drinking enough fluids, not waking up

Home Care Tips

If you have mild flu and aren't high-risk:

  • •Stay home to avoid spreading illness (usually 24 hours after fever resolves)
  • •Rest and sleep as much as possible
  • •Stay well-hydrated with water, clear broths, electrolyte drinks
  • •Use over-the-counter medications for symptom relief
  • •Acetaminophen or ibuprofen for fever and aches
  • •Avoid alcohol and tobacco

Flu Care at On Call Primary Care

As your primary care provider, I can evaluate your symptoms via telehealth and prescribe antivirals same-day if appropriate. This is especially important for high-risk patients who benefit most from early treatment.

Flu vaccines are available at our office and included in your membership. We strongly encourage all members to get vaccinated each fall.

Sources & References

    Last updated: Dec 8, 2025

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